Supplementary Figure 5: Robust SMRs capture ~95% of high-confidence SMRs from ten cancer types. | Nature Genetics

Supplementary Figure 5: Robust SMRs capture ~95% of high-confidence SMRs from ten cancer types.

From: Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations

Supplementary Figure 5

Robust SMRs are 58.8-fold enriched for somatic, SNV-driven Cancer Gene Census (CGC) genes (P = 2.4 × 10−34). (a) Overlap (blue) of robust SMRs (cyan) and high-confidence SMRs (gray). (b,c) Fraction of SMRs per cancer type classified as robust. Analyses in a and b are limited to high-confidence SMRs from the ten cancer types (green) with sufficient intronic mutation clusters for intron-based FDR estimation, as shown in b.

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