Supplementary Figure 8: Histogram of Gini coefficients of dispersion for nonsynonymous mutations per gene.

Gini coefficients were calculated on the basis of the number of nonsynonymous mutations contained per residue mutated in each cancer for CGC genes. For each CGC gene (n = 522), the maximum coefficient across cancers is plotted31,32. A set of outliers with extreme Gini coefficients is labeled. 81% of CGC genes with unassociated SMRs have Gini coefficients <0.1.