Supplementary Figure 10: Enrichment of CGC genes among SMR-based protein-coding drivers and SMR-identified binding interfaces. | Nature Genetics

Supplementary Figure 10: Enrichment of CGC genes among SMR-based protein-coding drivers and SMR-identified binding interfaces.

From: Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations

Supplementary Figure 10

(a) Fraction of SMR- and OncodriveCLUST-identified protein-coding genes in the Cancer Gene Census (CGC). OncodriveCLUST results were obtained from Tamborero et al.11. Driver analysis in endometrial (UCEC), ovarian (OVAR) and lung squamous cell carcinoma (LUSC) were performed with the same exome data sets. Breast cancer (BRCA) results were obtained with distinct sets of exome data sets and are therefore not directly comparable. (b) The fraction of SMR-identified and previously reported51 protein and DNA interaction interfaces with recurrent cancer somatic mutations. For direct comparison, we consider only interactions with nucleic acids and proteins. All CGC genes with previously reported51 somatically altered nucleic acid or protein interfaces are captured by SMRs (inset).

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