Supplementary Figure 12: NFE2L2 SMRs alter KEAP1-binding interfaces. | Nature Genetics

Supplementary Figure 12: NFE2L2 SMRs alter KEAP1-binding interfaces.

From: Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations

Supplementary Figure 12

The structures of SMR NFE2L2.1 (orange, shown here) and NFE2L2.2 (Fig. 4g) were mapped to NFE2L2 structures (PDB, 2FLU and 3WN7). A sector of recurrent lung adenoma alterations on KEAP1 (teal) with density score FDR ≤ 5% did not meet the 2% mutation frequency cutoff. The structure of NFE2L2.2 mapped to the mouse NFE2L2-KEAP1 co-crystal structure (PDB, 3WN7) is shown in Figure 4g.

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