Supplementary Figure 2: Background mutation models capture variance in somatic mutation rates and are well correlated. | Nature Genetics

Supplementary Figure 2: Background mutation models capture variance in somatic mutation rates and are well correlated.

From: Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations

Supplementary Figure 2

(a) Genome-wide transition/transversion mutation probabilities per tumor type. (b) Absolute difference in the log probabilities of complementary mutations (C>T and G>A) per gene in melanoma for the ‘Bayesian’ and 'Exonic' mutation probability models. The percentage of genes where complementary mutation probabilities are within one order of magnitude is indicated. (c) The median of Spearman correlations between the average ‘Bayesian’ and 'Matched' mutation probabilities in distinct tumor types is shown for the sets of tumor types with minimum numbers of samples (x axis). (d) Correlation between observed WGS intronic mutation probability (pan-cancer) and those of the ‘Bayesian’ (blue) or 'Matched' (gray) models.

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