Supplementary Figure 2: Phylogenetic reconstruction demonstrating the clonal evolution history of each of the five WES cases.
From: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
In each case, a phylogenetic tree was constructed using the somatic nonsynonymous variants detected in the WES analyses. All trees are rooted at the germline (GL) sequence, with the trunk of the tree representing variants shared by all the tumor biopsies, depicting a common ancestral origin. Internal branches indicate variants that are shared by more than one subsequent progressed or relapse tumor, and the terminal branches illustrate variants that are unique or phase specific to that biopsy alone. Early initiating genes are shown on the trunk of the tree. Novel genes identified in this study (RRAGC, ATP6V1B2 and ATP6AP1) are also illustrated. For RRAGC mutations, the superscript numbers in cases B2, B3 and B4 indicate the different RRAGC mutations identified in those individual biopsies.
