Supplementary Figure 4: Model of components of the amino acid–induced mTORC1 pathway.
From: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
At low amino acid levels (left), the Rag heterodimer (RagB-RagC) is in a nucleotide-bound configuration incompatible for the recruitment and activation of mTORC1. In the presence of sufficient amino acids (right), a supercomplex comprising the v-ATPase, Ragulator, SLC38A9 and the Rag GTPase heterodimer translocates to the lysosomal surface. This changes the Rag heterodimer into its active form with RagB being GTP bound and RagC being GDP bound, resulting in the recruitment and activation of mTORC1.
