Supplementary Figure 3: Association results for POAG in the NEIGHBORHOOD (stage 1) meta-analysis. | Nature Genetics

Supplementary Figure 3: Association results for POAG in the NEIGHBORHOOD (stage 1) meta-analysis.

From: Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Supplementary Figure 3

SNPs located in novel regions are colored pink, and those in previously known associated regions are colored green. The P values used to create this figure were corrected for the genomic inflation factor (λ = 1.06). Regions reaching genome-wide significance include one novel region (FOXC1) and three regions previously identified (TMCO1, CDKN2BAS and SIX6). The GAS7 region was previously associated with the quantitative risk factor for POAG, IOP. AFAP1 and ABCA1 previously associated with POAG did not reach genome-wide significance. ATXN2 and TXNRD2 surpassed the significance level of P < 1 × 10−5 at stage 1, along with other interesting regions, including 1p, 2p, 2q, 5p, 6p, 6q, 10q and 20p (3,853 cases and 33,480 controls).

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