Supplementary Figure 10: Residuals for MAE and BAE genes in a multivariate regression model of TMRCA values as a function of individual variables.
From: Genes with monoallelic expression contribute disproportionately to genetic diversity in humans
For each gene (blue, MAE; orange, BAE), mean TMRCA over the gene length was calculated from genome-wide TMRCA estimates generated by running ARGWeaver on Complete Genomics data9. The TMRCA estimates were log transformed for the regression analysis. All confounders except one (plotted on the x axis) were residualized for each panel. The intercept and slope of the MAE and BAE trend lines (solid line, MAE; dashed line, BAE) are from the multivariate regression model. The gap between trend lines represents a 1.06-fold increase in TMRCA for MAE as compared to BAE genes (P = 7.5 × 10−8). See the Online Methods for details on model covariates.
