Supplementary Figure 11: Identification of genes as MAE on the basis of their chromatin signature is consistent between unrelated individuals.
From: Genes with monoallelic expression contribute disproportionately to genetic diversity in humans
Comparison of the gene sets identified as MAE or BAE on the basis of ChIP-seq data in different individuals. Chromatin signature analysis was performed using ChIP-seq data from HapMap lymphoblastoid cell lines. Left bar, comparison of analyses performed on GM12878 (CEU) and GM19239 (YRI). Center bar, comparison of MAE and BAE calls obtained using ChIP-seq data from GM12878 (CEU) cells in ENCODE4 (same data set used in ref. 5) and in a biological replicate using the same cell line in another laboratory6 (“rep”). Right bar, the same gene set as in the center but additionally limited only to genes that show an expression level of RPKM >1 in GM12878 cells. BAE genes in both samples are shown in orange, MAE genes in both samples are shown in blue, genes that are MAE in the first listed sample but BAE in the other are shown in red; and genes that are BAE in the first listed sample but MAE in the other are shown in green. Only genes with calls made for both samples are used in this analysis. The numbers of genes in the major categories are shown.
