Supplementary Figure 4: MAE genes and extracellular matrix molecules.
From: Genes with monoallelic expression contribute disproportionately to genetic diversity in humans
(a) Genes encoding extracellular matrix molecules (ECM, Gene Ontology category GO:0031012) were strongly enriched for MAE genes (Fisher’s exact test, odds ratio = 8.09, P = 7.5 × 10−33). The total number of genes (Genome) and the number of genes associated with ECM are given in parentheses. (b) Genes showing signatures of a trans-species polymorphic haplotype (TSP) are significantly enriched for MAE genes. This enrichment remained even when excluding genes encoding extracellular matrix molecules (ECM, Gene Ontology category GO:0031012), a functional category that has previously been associated with balancing selection2. The total number of genes in each category is given in parentheses. Odds ratios and their significance level are reported (*P < 0.05, **P < 0.01).
