Supplementary Figure 8: Explanatory cartoon for Hi-C comparisons using the shifting alignment approach. | Nature Genetics

Supplementary Figure 8: Explanatory cartoon for Hi-C comparisons using the shifting alignment approach.

From: A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation

Supplementary Figure 8

The alignment of the Hi-C matrices being compared is iteratively shifted by bins of 20 kb (reaching ±25% of the total size of the matrix) to obtain a collection of ‘mock’ coefficients corresponding to misaligned Hi-C maps (from R–n to Rn), together with the coefficient of the correctly aligned comparison (R0). In this situation, R0 is expected to be the highest coefficient.

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