Supplementary Figure 7: TWAS power with expression and genetic component of expression.
From: Integrative approaches for large-scale transcriptome-wide association studies
Power to detect a genome-wide significant association is shown for summary-statistic TWAS using observed expression as well BLUP genetic value of expression. Left/right panels correspond to simulations with causal variants hidden/shown. Top/bottom panels correspond to simulations with each gene explaining 0.001/0.0005 of trait variance. x-axis shows simulations at increasing GWAS sample sizes (with expression panel fixed at 1,000 samples).
