Supplementary Figure 8: GWAS summary simulations with heritable expression independent of phenotype.
From: Integrative approaches for large-scale transcriptome-wide association studies
Expression and trait were simulated as having the same causal variants but independent effect-sizes and power evaluated. For a single causal variant, this model is statistically identical to a true causal model. Colors indicate the method used (see Supplementary Fig. 4). Left/right panels correspond to simulations with causal variants hidden/shown. Top/bottom panels correspond to simulations with each gene explaining 0.001/0.0005 of trait variance. x-axis shows simulations at increasing GWAS sample sizes (with expression panel fixed at 1,000 samples).
