Supplementary Figure 7: Effects of NUDT15 expression on mercaptopurine and thioguanine cytotoxicity.
From: NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
(a,b) NUDT15-knockdown (NUDT15 KD; red) cells were established by lentiviral transduction of NUDT15-specific shRNA, and control cells (black) were transduced with non-targeted vectors. Cytotoxicity was determined by MTT assay following incubation for 72 h with increasing concentrations of MP (a) and TG (b). Mean values are plotted in each panel; error bars, s.d. from triplicate experiments.
