Supplementary Figure 9: NUDT15 variants and mercaptopurine metabolism in children during ALL therapy.
From: NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
(a,b) DNA-TG levels were analyzed in the Singaporean (a) and Japanese (b) cohorts. Sixty-three and 44 samples were successfully measured from 32 cases with wild-type TPMT in the Singaporean and Japanese cohorts, respectively. An average DNA-TG level was estimated for each patient and then normalized on the basis of the tolerated MP dosage. The ratio of DNA-TG/MP dosage was plotted against the NUDT15 diplotypes. There were no significant differences in normalized DNA-TG between diplotypes within the intermediate-activity group (*1/*2, *1/*3 and *1/*5; P = 0.29) or within the low-activity group (*3/*5, *3/*3 and *2/*3; P = 0.37) in the combined cohorts using the Kruskal-Wallis test.
