Supplementary Figure 10: NUDT15 genotype was associated with the thioguanine sensitivity of primary ALL blasts in vitro.
From: NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
In 285 children with newly diagnosed ALL treated at St. Jude Children’s Research Hospital, primary leukemia cells at diagnosis were evaluated for sensitivity to TG using MTT assay as previously described (N. Engl. J. Med. 351, 533, 2004). NUDT15 genotype was summarized as diplotype (Online Methods), and its association with TG sensitivity (with LC50 as a continuous variable) was determined by a linear regression model (Online Methods).
