Supplementary Figure 6: Knockdown of NUP93 and its interactor NUP188 but not NUP153 impairs the migratory phenotype of human podocytes in vitro.
From: Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome
As compared to basal migration rate (dotted black line), the migration rate of human podocytes is increased after administration of serum as a chemoattractant (solid black line). Knockdown of NUP93 impairs the podocyte migration rate in vitro (blue line). Knockdown of NUP188, encoding a direct interaction partner of NUP93, causes a similar but less pronounced reduction in the cell migration rate (yellow line). In contrast, knockdown of the gene encoding the nuclear basket protein NUP153 does not affect cell migration (purple line).
