Supplementary Figure 1: QQ plots of P values from the SMR tests under a range of simulation scenarios.
From: Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
The simulation strategy is described in the Supplementary Note. Shown are the results from 10,000 simulations. MR one sample, Mendelian randomization analysis in one sample; SMR one sample, summary data–based Mendelian randomization analysis in one sample; SMR two samples, the effect sizes of a SNP on gene expression (βzx) and a SNP on phenotype (bzy) are estimated from two independent samples.
