Supplementary Figure 4: Effect of Leu129Gln CysLT2R on tumorigenesis and TPA independent of cell growth.
From: Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma
(a) Tumor volume of mice implanted with NIH3T3 cells expressing empty-vector, wild-type CysLT2R, Leu129Gln CysLT2R, or Arg136His CysLT2R (n = 10). Error bars, ±s.e.m. *P < 0.005. (b) Photographs of cellular pellets of melan-a cells expressing emptyvector, wild-type CysLT2R or Leu129Gln CysLT2R grown in the absence of TPA for 4 and 10 d.
