Supplementary Figure 3: Power of BUHMBOX as a function of effect size. | Nature Genetics

Supplementary Figure 3: Power of BUHMBOX as a function of effect size.

From: A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

Supplementary Figure 3

This plot shows the power of BUHMBOX for detecting heterogeneity in terms of the mean effect size and the proportion of samples that comprise a hidden subgroup (heterogeneity proportion, π). We assume that we have 2,000 cases, 2,000 controls, and 50 associated loci. We sampled OR and RAF values from the GWAS catalog and scaled all log-transformed OR values to have a desired mean value. White lines denote 20%, 40%, 60%, and 80% power.

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