Supplementary Figure 1: Quality control of FALS discovery cohort.
From: NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
Exome sequences were obtained for 1,376 FALS cases and 13,883 controls. Samples were excluded in the event of exome-wide call rate <70%, outlying heterozygosity (F <–0.1 or F >0.1), SNP-predicted and reported gender discrepancy, detectable relatedness to another retained sample (kinship coefficient ≥0.0442; ≥3rd-degree relationship), outlying ancestry with respect to FALS samples in pairwise tests of population concordance (exhibits P < 1 × 10−4 in tests with ≥10% of FALS cases; Supplementary Fig. 2) or outlying ancestry with respect to FALS samples in subsequent principal-components analysis (eigenvector value >4 s.d. from FALS mean along any of principal components 1–4).
