Supplementary Figure 2: Stratification analysis of FALS discovery cohort.
From: NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
(a) Results from first round of population outlier filtering. The y axis denotes the proportion of FALS samples for which a given test sample exhibits significant population discordance (P < 1.0 × 10−4 in pairwise population concordance testing). The x axis displays corresponding geographical labels for FALS cases. Horizontal dotted line denotes 10% FALS discordance threshold; all cases and controls falling above this line were removed during the first round of stratification filtering. (b) Distribution of FALS samples along eigenvectors 1 and 2 following principal-components analysis of the quality-control-filtered FALS discovery cohort. (c) Distribution of cases and controls along eigenvectors 1 and 2 following principal-components analysis of the quality-control-filtered FALS discovery cohort. AUS, Australia; BEL, Belgium; CAN, Canada; ESP, Spain; GER, Germany; IRL, Ireland; ITA, Italy; NLD, Netherlands; TUR, Turkey; UK, United Kingdom; USA, United States; USA_AFR, African American; USA_AMR, admixed American.
