Supplementary Figure 4: High-confidence interactions found in the STRING PPI database in top-ranking set of CHD-associated genes.

Edges in the graph represent high confidence (STRING score > 0.9) protein-protein interactions between top ranking genes (FDR < 50%) in the integrated de novo and inherited variant analysis. Known CHD-associated genes are colored blue, other nodes are scaled according to their association FDR. The size of nodes is scaled by its degree.