Supplementary Figure 5: Saturation analysis for detecting haploinsufficient S-CHD-associated genes. | Nature Genetics

Supplementary Figure 5: Saturation analysis for detecting haploinsufficient S-CHD-associated genes.

From: Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

Supplementary Figure 5

A box plot showing the distribution of statistical power to detect a significant enrichment of PTV mutations across 19252 genes in the genome, for different numbers of trios studied, from 500 trios to 10,000 trios. Line within the box shows the median, box corresponds to the first and third quartiles (the 25th and 75th percentiles) and whiskers correspond to most extreme values within 1.5 times the interquartile range from the box.

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