Supplementary Figure 6: The rs7463708 locus overlaps with the PCAT1 enhancer region.
From: Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer
(a) Survival analysis by rs7463708 showed that the risk allele (blue) is associated with worse BCR rates. “1” (red) indicates patients homozygous for the non-risk alleles of rs7463708 and rs72725879 (the SNP with the strongest LD with rs7463708), and “0” (blue) indicates the remaining patients. A Cox proportional hazards model was fit to compare BCR rates between the two patient groups (HR = 0.52, 95% confidence interval = 0.26–1.06; P = 0.071, Wald test). (b) AR, HOXB13 and FOXA1 bind to the DHS containing rs7463708, rs1456315 and rs72725879. (c) Sanger sequencing results show that rs7463708 is the only heterozygous SNP in this DHS.
