Supplementary Figure 9: Characterization of the PCAT1 distal enhancer in the rs7463708 locus.
From: Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer
(a) ONECUT2 has the highest expression in the ONECUT family and is upregulated in prostate tumors in comparison to benign prostate tissues. Data used here are prostate cancer RNA-seq data from TCGA. (b) AR ChIP-seq analysis in LNCaP cells shows that AR binding in the rs7463708 locus is induced by DHT stimulation. (c) AR preferentially binds to the T risk allele of rs7463708, as determined by allele-specific ChIP–qPCR. P value was calculated by Student’s t test: *P < 0.05, **P < 0.01.
