Supplementary Figure 10: GWAS enrichments across hematopoiesis.

(a) Representative example of GWAS enrichment across tissues. Fold enrichment (see the Online Methods for description of the calculation) is calculated from increasingly stringent GWAS SNP associations within different tissues. Line color represents tissue as shown in b. (b) Hierarchical clustering of row-normalized, rank fold enrichment values (Online Methods), for all GWAS collected (n = 235) across diverse tissues. The colored dendrogram and color bar below denote GWAS enriched in blood cells. (c) Summary of GWAS deviations across hematopoiesis. Scores are normalized by the maximum and minimum (range) across the 13 cell types assayed, such that the values shown range from 0 to 1. The range for the raw scores is shown above each column. Raw values can be found in Supplementary Table 3.