Supplementary Figure 7: Super-enhancers with concordant changes in gene expression that are more active in meningiomas compared to dura.
From: Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
(a-c) Shading represents high confidence super-enhancers that were detected in at least 2 samples per subgroup. Chromosomal coordinates are hg19. (d-e) Concordant differential gene expression and differentially-bound super enhancers between meningioma subgroups. Red points represent a differentially highly bound super-enhancer (FDR < 0.05) with concordant up-regulation of its nearby target gene (FDR < 0.05). Blue points represent a differentially lower bound super-enhancer that correlates with down-regulation of its target gene.
