Supplementary Figure 9: Identification of putative driver genes and mutations.
From: Unsupervised detection of cancer driver mutations with parsimony-guided learning
Genes are plotted by the average ParsSNP score of their mutations and their single highest score in the entire pan-cancer data set (training + test + hypermutator). The top ParsSNP scoring mutations are generally found in members of the CGC. Two genes not belonging to the CGC have multiple exceptional mutations (arrows): TATA-box-binding protein (TBP) and the calcium-activated potassium channel KCNN3. Both have significantly higher median ParsSNP scores than expected by chance (Bonferroni-corrected one-sample Wilcoxon P < 0.05) and multiple mutations with exceptionally high ParsSNP scores, including TBP A191T (ParsSNP = 0.75) and R168Q (0.67), as well as KCNN3 R435C (0.60), L413Q (0.59), and S517Y (0.53).
