Supplementary Figure 12: Criteria for thresholding ParsSNP scores.
From: Unsupervised detection of cancer driver mutations with parsimony-guided learning
(a) The E-step constraints are one possible objective criterion for thresholding ParsSNP scores. The value to be optimized is the percentage of samples receiving a number of driver mutations that is compatible with the E-step upper and lower bounds under the proposed threshold. (b) Another approach is to select a threshold that optimizes accuracy (correct classification rate) in the classification tasks.
