Supplementary Figure 2: Linkage analysis in seven families.

Nonparametric linkage analysis was performed using the Merlin package in five pairs of affected siblings (F331, F426, F454, F521 and F780) born to unrelated parents and two singletons (F344 and F446) who were the product of independent consanguineous unions. K&C lin, Kong and Cox linear model; K&C exp, Kong and Cox exponential model.