Supplementary Figure 9: Unsupervised hierarchical clustering of methylation values at shared probes.

‘Shared’ probes were those selected as having similar values across different regions of the same tumor (the number of shared probes is given above each heat map as n). The shared probes were compared to normal adjacent tissue and divided into those that had consistently higher methylation values (hypermethylated) or lower methylation values (hypomethylated) in the tumor samples. The probes in each heat map were clustered using hierarchical clustering with the Euclidean distance metric.