Supplementary Figure 1: Fitting somatic variants to evolutionary models based on phylogenetic trees.

Mutations that were mapped to the shared and private branches of trees and were 100% compatible with tree structure are shown on the branch where they occurred; those incompatible with tree structure are not shown. As trunk variants were defined by their presence in all regions, they were by definition consistent and are not shown because of space limitations. The total number of mutations in each case and the percentage that were compatible with the evolutionary tree model are provided above each tree (in parentheses).