Supplementary Figure 12: Fusion-positive HEI-193 cells lose Schwann cell markers. | Nature Genetics

Supplementary Figure 12: Fusion-positive HEI-193 cells lose Schwann cell markers.

From: The genomic landscape of schwannoma

Supplementary Figure 12

(a) Fusion-positive HEI-193 cells but not empty vector-expressing control cells form tumors in flank of NOD-SCID mice. (b) Immunoblotting of HEI-193 control and SH3PXD2A-HTRA1 fusion-positive cells for S100B and HA tag. (c) Immunoblotting of Schwann cells with empty vector control and SH3PXD2A-HTRA1 fusion-positive cells for S100B and HA tag. (d) H3K27me3 immunoblot confirms both fusion-positive and fusion-negative cells from patient samples have similar trimethylated histones, a functional readout of the PRC2 complex.

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