Supplementary Figure 14: Fusion-positive cells are sensitive to trametinib. | Nature Genetics

Supplementary Figure 14: Fusion-positive cells are sensitive to trametinib.

From: The genomic landscape of schwannoma

Supplementary Figure 14

(a) Immunoblot of HEI-193 and Schwann cells expressing empty vector controls, wild-type HTRA1 or SH3PXD2A. (b) Trametinib IC50 values for cells expressing empty vector, HTRA1 or SH3PXD2A. (c) Immunoblot of HEI-193 empty vector control or fusion expressing cells transfected with N-FLAG tagged NF2 full length cDNA. (d) Doubling time of control HEI-193 cells and cells expressing NF2, fusion or both. (e) Immunoblot Schwann cells expressing empty vector or the fusion expressing transfected with NF2 shRNA. (f) Doubling time from control Schwann cells, NF2 knockdown cells, fusion-positive cells and fusion-positive/NF2 knockdown cells.

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