Supplementary Figure 4: Unsupervised clustering of schwannomas based on DNA methylation. | Nature Genetics

Supplementary Figure 4: Unsupervised clustering of schwannomas based on DNA methylation.

From: The genomic landscape of schwannoma

Supplementary Figure 4

(a,b) Change in Gini coefficient plot from k = 2 to k = 8 (a) and cumulative distribution function (CDF) plots generated from consensus k-means clustering (b) identifies strongest statistical support for the existence of two subgroups of schwannomas. (c) Non-negative matrix factorization (NMF) of the 1,500 most variable CpG probes supports two subgroups of schwannoma (cophenetic coefficient = 0.9997 at k = 2). (d) Cophenetic coefficient plot support two subgroups of schwannoma and stability of two clusters using different variable CpGs for clustering. (k denotes the number of clusters).

Back to article page