Supplementary Figure 7: Associations of the genetic scores comprising the 53 or 43 SNPs with glycemic and anthropometric traits in large-scale meta-analyses and in the Fenland study.

(a) Association of the genetic scores with anthropometric and glycemic traits in meta-analyses of genetic association studies. Body mass index, waist–hip ratio, and waist and hip circumference data are from the GIANT consortium and the UK Biobank study. Body fat percentage data are from the UK Biobank, EPIC-Norfolk and Fenland studies. Fasting plasma glucose, 2-h glucose and HbA1c data are from the MAGIC consortium. Leg fat mass data are from the EPIC-Norfolk and Fenland studies. Squares with error bars represent the per-allele β coefficients in standard deviation units and their 95% confidence intervals. (b) Association with the same traits in participants of the Fenland study not included in the discovery efforts that contributed to the identification of the 53 loci. Because HbA1c has been measured only in a subset of Fenland participants, the HbA1c analysis also includes individuals from the InterAct study subcohort who did not take part in the discovery efforts that contributed to the identification of the 53 loci. Squares with error bars represent the per-allele β coefficients in standard deviation units and their 95% confidence intervals. Red and blue squares represent the results of the 53-SNP and 43-SNP genetic scores, respectively. None of the results presented in the figure were adjusted for body mass index. N, number of participants; SD, standard deviation; BMI, body mass index; WHR, waist–hip ratio; FPG, fasting plasma glucose.