Supplementary Figure 11: Mechanistic hypothesis for the implication of putative effector genes in the observed associations and selection of genes for experimental validation in cellular models of adipogenesis. | Nature Genetics

Supplementary Figure 11: Mechanistic hypothesis for the implication of putative effector genes in the observed associations and selection of genes for experimental validation in cellular models of adipogenesis.

From: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Supplementary Figure 11

(a) Mechanistic hypothesis. (b) Selection criteria to prioritize genes for experimental validation. (c) Selection flowchart. Numbers in c refer to loci meeting certain selection criteria. *We did not take forward the KLF14 gene to experimental validation because previous studies on the role of this gene in metabolic disease suggest complex etiological mechanisms at this locus, including a possible parent-of-origin effect.

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