Supplementary Figure 12: Associations with fasting insulin adjusted for body mass index, body mass index or fasting insulin of the 53 polymorphisms identified in this study. | Nature Genetics

Supplementary Figure 12: Associations with fasting insulin adjusted for body mass index, body mass index or fasting insulin of the 53 polymorphisms identified in this study.

From: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Supplementary Figure 12

(a) Association of the 53 lead polymorphisms from our study with FIadjBMI as a function of the association with BMI. There was no clear bias in the association with FIadjBMI (linear regression between the β coefficients of the 53 polymorphisms, P = 0.26). (b) Association with FI (unadjusted for BMI) of the lead 53 polymorphisms as a function of the association with FIadjBMI. The line of fit was aligned with the line of equality consistent with no bias. In a, the dark red line and surrounding areas represent the line of fit with 95% confidence areas. The dashed gray line in b represents the line of equality. Data on fasting insulin associations are from the MAGIC consortium; data on BMI associations are from the GIANT consortium.

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