Supplementary Figure 3: Combined directional Manhattan plots of the association with insulin-resistance-related phenotypes. | Nature Genetics

Supplementary Figure 3: Combined directional Manhattan plots of the association with insulin-resistance-related phenotypes.

From: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Supplementary Figure 3

(a–c) Manhattan plots of the association of SNPs with fasting insulin adjusted for body mass index (FIadjBMI) (a), triglycerides (b) and HDL cholesterol (c). We plotted only variants with FIadjBMI, triglycerides and HDL cholesterol (P < 0.005 for each phenotype). All associations are represented for the FIadjBMI-raising allele. The 630 alleles associated with higher FIadjBMI, higher triglycerides and lower HDL cholesterol are plotted in dark red. The graph also plots 21 variants that met the P-value threshold for the three phenotypes but were not associated in the required direction (gray). For graphic display purposes, P values below 10−20 are represented as 10−20.

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