Supplementary Figure 5: Cancer-type-specific CESAM analysis of gene expression changes for structural variants versus control of IRS4 locus-proximal genes. | Nature Genetics

Supplementary Figure 5: Cancer-type-specific CESAM analysis of gene expression changes for structural variants versus control of IRS4 locus-proximal genes.

From: Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

Supplementary Figure 5

Related to main Figure 3. IRS4, COL4A5, COL4A6, VSIG1, PSMD10 and ATG4A expression values (RSEM) for SVs and controls, shown for different cancer types as well as for the pan-cancer setting. IRS4 represents the most consistently upregulated gene, and SCNAs clearly appear to converge on IRS4 overexpression at this extended genomic locus, implicating IRS4 as a plausible candidate gene.

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