Supplementary Figure 7: Diffusion tensor tractography.
From: Biallelic mutations in human DCC cause developmental split-brain syndrome
(a,b) Diffusion Tensor Imaging (DTI) of the corpus callosum, obtained by placing a region of interest on the four midline sagittal slices; left and right hemisphere contribution to the tracts were visualized (two left hemisphere slices, two right hemisphere slices) and pseudocolored yellow and blue. A mixture of yellow and blue fibers, representing the left and right hemisphere tract reconstructions, and the presence of red fibers indicate a well-defined interhemispheric crossing in the control. In individual II:1 from Family 2, there appears to be no midline region of interest corresponding to the corpus callosum. Instead, in each hemisphere, a distinct longitudinal tract known as the Probst bundle can be visualized; each hemisphere seems to have a separate connection to the frontal, motor strip, and occipital areas, but these fibers do not extend into the contralateral hemisphere. Solid white line: genu of corpus callosum. Dashed white line: splenium of corpus callosum. Dashed orange line: anterior commissure.
