Supplementary Figure 4: Full-length gels and blots with molecular weight standards showing the effect of the ABL1 variants (isoform 1b) on phosphorylation. | Nature Genetics

Supplementary Figure 4: Full-length gels and blots with molecular weight standards showing the effect of the ABL1 variants (isoform 1b) on phosphorylation.

From: Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations

Supplementary Figure 4

The multiple non-specific bands seen in full blots of p-ABL1 and p-STAT5 from cells expressing ABL1-1bTyr245Cys and ABL1-1bAla356Thr (but not in wild-type cells) may represent non-specific proteins resulting from the increased activity of both ABL1-1bTyr245Cys and ABL1-1bAla356Thr.

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