Supplementary Figure 4: Enrichment in germline cancer predisposition genes.
From: Estimating the selective effects of heterozygous protein-truncating variants from human exome data
In a large screen of germline cancer predisposition genes in the Pediatric Cancer Genome Project (PCGP), the enrichment of variants in pediatric cancer cases is measured over individuals in ExAC. Genes with greater enrichment of variants in cancer cases over ExAC are correlated with higher selection coefficients. Data are separated by shet bins on a log scale. Box plots range from 25th-75th percentile values and whiskers include 1.5 times the interquartile range.
