Supplementary Figure 7: Most and least published genes from top shet decile.
From: Estimating the selective effects of heterozygous protein-truncating variants from human exome data
The proportion of annotations related to genes with the fewest and most publications in Entrez Gene. From the set of genes under the strongest selection (top 10% of shet values), we create two sets of 250 genes. The first set of genes has the fewest publications associated with each gene, as defined by our PubMed gene score ( Methods ), and the second set has the greatest number of associated publications. Between the two groups, we compare the shet values, number of protein-protein interactions, viability of orthologous mouse knockouts (IMPC), and cell essentiality assays (KBM-7 CRISPR score and Gene Trap Score). These results suggest that the genes in the least published set are similar to those in the most published set, and are also potentially important developmental genes.
