Supplementary Figure 11: Inferred distribution of fitness effects for heterozygous loss of gene function when excluding Finnish individuals.
From: Estimating the selective effects of heterozygous protein-truncating variants from human exome data
We re-generated estimates of the distribution of heterozygous selection coefficients shet using the set of PTVs from all individuals in ExAC (N=60,706) and the set that excludes all Finnish individuals (N=57,399), using ExAC version 0.3.1 with LOFTEE annotations. Estimates of parameters from maximum likelihood fit to the observed distribution of PTV counts n across genes with 
=n/N<0.001, assuming shet~IG(α,β). We find no substantial difference in the estimation of the prior for the distribution of selection coefficients in the ExAC sample that excludes Finnish individuals.
