Supplementary Figure 7: Dose-response plots for Mendelian randomization analyses. | Nature Genetics

Supplementary Figure 7: Dose-response plots for Mendelian randomization analyses.

From: Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Supplementary Figure 7

(a–d) The individual effects on AAM of the 314 ‘BMI-unrelated’ autosomal AAM variants are plotted against risks for breast (a), prostate (b), endometrial (c) and ovarian (d) cancer. Red line, IVW regression; blue line, MR-Egger regression. MR-Egger supports the protective effect of later age at puberty on breast, prostate and endometrial cancers, but indicates pleiotropy in the association with ovarian cancer.

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