Supplementary Figure 6: Association of menarche-associated variants with adult body mass index.

The blue bars (and left y axis) indicate the collective variance explained in adult BMI (with bootstrap-generated 95% CIs) by index menarche-associated SNPs grouped by their individual associations with BMI (in UK Biobank using an additive model controlling for chip and principal components). The red line (and right y axis) indicates the –log10 P value for the collective association with BMI of each group of SNPs. Purple squares correspond to collective associations with BMI at P < 0.05.