Supplementary Figure 11: Atrial fibrillation–associated loci are enriched for functional elements. | Nature Genetics

Supplementary Figure 11: Atrial fibrillation–associated loci are enriched for functional elements.

From: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Supplementary Figure 11

(a–f) Median overlap of loci by phastCons 46-way primate conserved elements (a), phastCons 46-way mammalian conserved elements (b), Roadmap Epigenomics cardiac H3K27ac gapped peaks (R atrium, L ventricle, R ventricle, aorta) (c), any Roadmap Epigenomics H3K27ac gapped peak (98 cell types) (d), ENCODE DNaseHS cardiac sites (cardiac fibroblasts, atrial fibroblasts, cardiac myocytes) (e), and ENCODE DNaseHS master sites (125 cell types) (f). *P < 0.05, **P < 0.01, ***P < 0.001, one-tailed bootstrapping (n = 1,000). Whiskers, interquartile range; AF, atrial fibrillation–associated loci (n = 24); GWAS, NHGRI-EBI GWAS catalog associated loci (n = 3,381); 1000G, 1000 Genomes control loci based on SNPsnap matched variants to atrial fibrillation GWAS hits (n = 9,093).

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